Active Cdc42 binds to the CRIB domain of PAK1, causing the kinase to alter its conformation, and thus relieve its own autoinhibition.

This model was created by using structural information provided by The Protein Data Bank
H.M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov, P.E. Bourne:The Protein Data Bank. Nucleic Acids Research, 28pp. 235-242 (2000)

Lei, M., Lu, W., Meng, W., Parrini, M-C., Eck, M. J., Mayer, B. J., Harrison, S. C.: Structure of Pak1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch Cell (Cambridge,Mass.) 102 pp. 387 (2000)

Morreale, A., Venkatesan, M., Mott, H. R., Owen, D., Nietlispach, D., Lowe, P. N., Laue, E. D.: Solution Structure of Cdc42 Bound to the Gtpase Binding Domian of Pak Nat.Struct.Biol. 7 pp. 384 (2000)
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