Active Cdc42 binds to the CRIB domain of PAK1, causing the kinase to alter its conformation, and thus relieve its own autoinhibition.
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This
model was created by using structural information provided by The
Protein Data Bank |
H.M. Berman, J. Westbrook, Z. Feng,
G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov, P.E. Bourne:The
Protein Data Bank. Nucleic Acids Research, 28pp. 235-242 (2000) |
Lei, M., Lu, W., Meng, W., Parrini, M-C., Eck, M. J., Mayer, B. J., Harrison, S. C.: Structure of Pak1 in an Autoinhibited Conformation Reveals a Multistage Activation Switch Cell (Cambridge,Mass.) 102 pp. 387 (2000) |
Morreale, A., Venkatesan, M., Mott,
H. R., Owen, D., Nietlispach, D., Lowe, P. N., Laue, E. D.: Solution
Structure of Cdc42 Bound to the Gtpase Binding Domian of Pak Nat.Struct.Biol.
7 pp. 384 (2000) |
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